MWF 1-2pm,120 Morgan

Molecular Toxicology
Modern industry, agriculture, and medicine use an ever-increasing array of synthetic and natural chemicals. Many of these compounds are potentially hazardous to our health. Molecular toxicology attempts to understand the mechanisms by which hazardous compounds cause their toxic effects. The use of molecular methods, and recent advances, such as the Human Genome Project, are transforming our ability to understand and predict the effects of chemicals on human health. The course will focus on our evolving understanding of the important tissue and cellular components involved in chemical exposure from entry to effect to exit. Specific topics to be addressed include:

• Metabolism of toxins including bio-transformation and transport
• Molecular assays of toxicity
• Mechanisms of Toxicity including
• mutations and cancer
• hormone disrupting chemicals and reproduction
• Use of information and tools of human genome project
• Differences in individuals and populations in toxin effects
• Computational tools to predict toxicology

Course Readings

Lecture Presentations