Nutritional Sciences & Toxicology 160:
Human Nutrition: Normal Physiology and Pathophysiology of Disease - 3 Units

Lecture:
Monday, Wednesday and Friday 3:00-4:00pm, at 105 Northgate Hall

Instructors and Office Hours
Marc Hellerstein
Professor, Department of Nutritional Sciences and Toxicology
office phone: 643-2550
E-mail: march@nature.berkeley.edu
325 Morgan Hall
Office Hours: By Appointment, 325 Morgan Hall

Robert Ryan
Adjunct Professor, Department of Nutritional Sciences and Toxicology
office phone: 642-7870; or at CHORI 450-7645
E-mail: rryan@chori.org
233 Morgan Hall
Office Hours: MWF 4-5, 233 Morgan Hall

Elizabeth C. Theil
Adjunct Professor, Department of Nutritional Sciences and Toxicology
office phone: 642-7870; or at CHORI 450-7670
E-mail: etheil@chori.org
233 Morgan Hall
Office Hours: MWF 4-5, 233 Morgan Hall

Graduate Student Instructor
Michael Griffin
Email: eggman@berkeley.edu
27 Morgan Hall
Office hours: Thursday 1-2 p.m.

Textbooks and Readings:
Primary Textbook: Insel, P., R.E. Turner, and D. Ross. Nutrition, 2nd Ed. Jones & Bartlett Publishers, 2004.
Secondary Texts: Groff, J.L. and S.S. Gropper. Advanced Nutrition and Human Metabolism. (Library Reserve)
Reader from Copy Central.

Course Description:
This course covers the biochemical and physiologic basis of human nutritional requirements and nutritional disorders. The focus will be on the underlying metabolic principles that explain the pathophysiology and treatment of common nutritional disorders in contemporary human societies. Integrated aspects of metabolism in the whole organism will be emphasized. Case studies for selected topics of special interest or controversy will be presented. Both textbooks and primary literature sources will be used. Emphasis will be on the mechanistic basis and published evidence behind current understanding and practice.

NST 160:
Human Nutrition: Normal Physiology and Pathophysiology of Disease
Lecture Schedule

Date	Instructor	Topic	Reading
		I. Energy Homeostasis
Aug 30	Hellerstein	Basic Principles: Homeostasis, Metabolic Pathways, Evidence in Biomedicine
Sept 1	Hellerstein	Body Composition and Constituents
Sept 3	Hellerstein	Energy Balance: Dynamic Nature
Sept 8	Hellerstein	Altered Body Composition I) Obesity and Its Consequences
Sept 10	Hellerstein	Altered Body Composition II) Body Fat Distribution
Sept 13	Hellerstein	Metabolic Syndrome and Insulin Resistance: The Modern Epidemic
Sept 15	Hellerstein	Diet and Drug Therapy of Obesity; Case Study Diet and Drug Therapy of Obesity; Case Study
		II. Vitamins and Lipids
Sept 17	Ryan	Vitamin D
Sept 20	Ryan	Vitamins E and K
Sept 22	Ryan	Vitamin A and Retinoids
Sept 24	Ryan	Lipids – Basic Physiology
Sept 27	Ryan	Lipoproteins, Cardiac Risk
Sept 29	Ryan	Case Study: Lipids and Cardiovascular Disease
Oct 1		Midterm Exam #1	Exam Key
		III. Trace Elements in Nutrition (Bioinorganic Chemistry of Food and Physiology)
Oct 4	Theil	Iron	Read Insel Ch12 & Theil, ARN 24:327-43, 2004
Oct 6	Theil	Iron Nutrition and Physiology	Read Miret et al. ARN 23:283-301, 2003
Oct 8	Theil	Iron-Deficiency Anemia
Oct 11	Theil	Zinc	Read Liuzzi & Cousins. ARN 2004;24:151-72 For Oct 11-15, read Finney & O'Halloran. Science 2003;300:931-6
Oct 13	Theil	Copper	Mercer & Llanos. J Nutr 2003;133:1481S-4S and Puig & Thiele. Curr Op Chem Biol 2002;6:171-80
Oct 15	Theil	Manganese and Other Trace Metals
		IV. Protein Metabolism
Oct 18	Hellerstein	Nitrogen and Protein Economy	IDA Case Study Answers
Oct 20	Hellerstein	Starvation and Protein-Energy Malnutrition
Oct 22	Griffin	Metabolic Regulatory Circuits	Saltiel & Kahn. Nature 2001;414:799-806
Oct 25		Midterm Exam #2	Exam Key
		V. Micronutrients
Oct 27	Theil	Selenium - Physiology and Nutrition	Driscoll & Copeland. Annu Rev Nutr 2003;23:17-40
Oct 29	Theil	Selenium - Biological Incorporation
Nov 1	Theil	Ascorbate/Pro-oxidants	Subramanian et al. J Biol Chem 2004;279:27719-28
Nov 3	Theil	Calcium and Bone Metabolism
Nov 5	Theil	Calcium and Bone Metabolism
Nov 8	Theil	Case study- Ca, P; Review: Se, Vit C, Ca/P
		VI. Topics in Nutrition
Nov 10	Ryan	Pregnancy and Lactation
Nov 12	Ryan	Alcohol
Nov 15	Ryan	Anti-oxidants
Nov 17	Ryan	Genetically Modified Foods
Nov 19	Ryan	Genetically Modified Foods
		VII. Miscellaneous
Nov 22	Hellerstein	Dietary Carbohydrates and Blood Lipids	Parks & Hellerstein. Am J Clin Nutr 2000;71:412-33.
Nov 29	Hellerstein	Diet and Cancer
Dec 1	Ryan	Malnutrition	Ryan's lecture notes
Dec 3	Hellerstein	TBA
Dec 6		Midterm Exam #3	Exam Key
Dec 8	TBD	TBA
Dec 10	TBD	TBA	Theil Review slides

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