The June 23rd issue of Molecular Cell contains a ‘preview’ by John Richardson of the Mechanochemistry of Transcription Termination Factor Rho, highlighting our experimental and modeling efforts.

I am funded by the DOE’s Computational Science Graduate Fellowship and one of the great perks of the program is the annual Fellows’ Conference , held in Washington, DC which allows this rather eclectic group to present their research in a highly interdisciplinary setting. This year I presented my preliminary work on modeling DNA […]

Adelman, J.L, et al. (2006) Molecular Cell 22(5):611-621 :: Rho is a ring-shaped hexameric motor protein that translocates along nascent mRNA transcript and terminates transcription of select genes in bacteria. Using a numerical optimization algorithm that simultaneously fits all of the presteady-state ATPase kinetic data, we determine how Rho utilizes the chemical energy of ATP […]