I am funded by the DOE’s Computational Science Graduate Fellowship and one of the great perks of the program is the annual Fellows’ Conference , held in Washington, DC which allows this rather eclectic group to present their research in a highly interdisciplinary setting. This year I presented my preliminary work on modeling DNA Translocases which is a collaborative project with Andrew Spakowitz and members of the Bustamante Lab. Investigating the mechanochemistry of motor proteins by developing simple coarse-grained models is an ongoing theme in my research. This work extends the pure kinetic modeling used in my previous work to couple the conformational dynamics of the protein to the chemical cycle of individual subunits in order to elucidate the effects of external force on the protein’s behavior.
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Joshua L. Adelman