End-stage chronic liver disease manifested by cirrhosis and liver cancer (HCC) claims more than 1.5M lives globally. A mesenchymal liver cell type critical in pathologic progression to cirrhosis to HCC, is hepatic stellate cell (HSC) which functions as a vitamin A-storing pericyte in the normal liver but undergoes myofibroblast (MFB) trans-differentiation to participate in liver fibrogenesis and tumor promotion.