Ph.D. (Neuroscience), Emory University, 2007
Olzmann, J.A., Richter, C.M., Shaler, T.A., Kopito, R.R. (2013) Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Proc. Natl. Acad. Sci. 110(4), 1345-50.
Tyler, R.E., Pearce, M.M.P., Shaler, T.A., Olzmann, J.A., Greenblatt, E.J., Kopito, R.R. (2012) Unassembled CD147 is an endogenous ER-associated degradation (ERAD) substrate. Mol. Biol. Cell 23(24), 4668-78.
Olzmann, J.A., Kopito, R.R., Christianson, J.C. (2012) The mammalian ERAD system. Cold Spring Harb. Perspect. Biol. cshperspect.a013185v1.
Greenblatt, E.J., Olzmann, J.A., Kopito, R.R. (2012) Making the cut: Intramembrane cleavage by a rhomboid protease promotes ERAD. Nat. Struc. Mol. Biol. 19(10), 979-981.
Christianson, J.C.*, Olzmann, J.A.*, Shaler, T.A., Sowa, M.E., Bennett, E.J., Richter, C.M., Tyler, R.E., Greenblatt, E.J., Harper, J.W., Kopito, R.R. (2012) Defining human ERAD networks through an integrated mapping strategy. Nat. Cell Biol. 14(1), 93-105. * These authors contributed equally.
Greenblatt, E.J., Olzmann, J.A., Kopito, R.R. (2011) Derlin-1 is a rhomboid protein required for dislocation of mutant -1-antitrypsin from the endoplasmic reticulum. Nat. Struc. Mol. Biol. 18(10), 1147-1152.
Lee, S.M., Olzmann, J.A., Chin, L.S., Li, L. (2011) Charcot-Marie-Tooth disease-associated mutations cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J. Cell Sci. 124, 3319-3331.
Olzmann, J.A., Kopito, R.R. (2011) Lipid droplets are dispensable for endoplasmic reticulum-associated degradation. J. Biol. Chem. 286, 27872-27874.
Chin, L.S., Olzmann, J.A., Li, L. (2010) Parkin-mediated ubiquitin signaling in aggresome formation and autophagy. Biochem. Soc. Trans. 48(1), 144-149.
Wang, Y., Pearce, M.M., Sliter, D.A., Olzmann, J.A., Christianson, J.C., Kopito, R.R., Boeckmann, S., Gagen, C., Leichner, G.S., Roitelman, J., Wojcikiewicz, R.J. (2009) An ER membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of IP3 receptors. Biochim. Biophys. Acta. 1793(11), 1710-8.
Kim, B.Y., Olzmann, J.A., Choi, S.I., Ahn, S.Y., Kim, T.I., Cho, H.S., Suh, H., Kim, E.K. (2009) Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J. Biol. Chem. 284,19580-19591.
Olzmann, J.A., Li, L., Chin, L.S. (2008) Molecular mechanisms of aggresome formation; Implications for neurodegenerative diseases. Curr. Med. Chem. 15(1), 47-60.
Olzmann, J.A., Chin, L.S. (2008) Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway. Autophagy 4(1), 85-87.
Olzmann, J.A., Li, L., Chudaev, M., Perez, F.A., Palmiter, R. D., Chin, L.S. (2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding HDAC6. J. Cell Biol. 178, 1025-1038.
Pridgeon, J.W.*, Olzmann, J.A.*, Chin, L.S., Li, L. (2007) PINK1 protects against oxidative stress-induced apoptosis by phosphorylating mitochondrial chaperone TRAP1/Hsp75. PLoS Biol. 5, e172. * These authors contributed equally.
Kim, B.Y.*, Olzmann, J.A.*, Barsh, G.S., Chin, L.S., Li, L. (2007) Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol. Biol. Cell 18, 1129-1142. * These authors contributed equally.
Olzmann, J.A., Bordelon, J.R., Muly, E.C., Rees, H.D., Levey, A.I., Li, L, Chin, L.S. (2007) Enrichment of DJ-1 protein in primate striatal neuronal processes: Implications for Parkinson’s disease. J. Comp. Neurol. 500, 585-599.
Choi, J., Sullards, C.M., Olzmann, J. A., Rees, H.D., Weintraub, S.T., Bostwick, D.E., Gearing, M., Levey, A.I., Chin, L.S., Li, L. (2006) Oxidative damage of DJ-1 is linked to sporadic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 281, 10816-24.
Vincent, A.M., Olzmann, J.A., Brownlee, M., Sivitz, W.I., and Russell, J.W. (2004) Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes 53, 726-734.
Olzmann, J.A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., and Chin, L.S. (2004) Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J. Biol. Chem. 279, 8506-8515.
Russell, J.W., Golovoy, D., Vincent, A. M., Mahendru, P., Olzmann, J.A., Mentzer, A., and Feldman, E. L. (2002) High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J. 16, 1738-1748.
